We offer advanced design and quality synthesis for predesigned siRNA and siRNA libraries using the Rosetta siRNA Design Algorithm to reduce offtarget effects and increase RNAi performance The algorithm utilizes PositionSpecific Scoring Matrices (PSSM) and knowledge of the siRNA seed region to predict the most effective and specific siRNAThe siRNA Nonseed Region and Its Target Sequences Are Auxiliary Determinants of OffTarget Effects PLoS Comput Biol 15 Dec 11;11(12)e doi /journalpcbi eCollection 15 Dec Authors Piotr J Kamola 1 Several recent studies suggest that the main source of siRNAmediated offtarget gene silencing could be the complementation between the 'seed' region of
Frontiers Sirna Design Software For A Target Gene Specific Rna Interference Genetics
